Notch signaling occurs through direct interaction between Notch, the receptor, and its
ligands, presented on the surface of neighboring cells. Endocytosis has been shown to be
essential for Notch signal activation in both signal-sending and signal-receiving cells, and
numerous genes involved in vesicle trafficking have recently been shown to act as key
regulators of the pathway. Defects in vesicle trafficking can lead to gain-or loss-of-function
defects in a context-dependent manner. Here, we discuss how endocytosis and vesicle …